Janey Wiggs
Dr. Wiggs received her Ph.D. in Biochemistry from the University of California, Berkeley and her M.D. from Harvard Medical School. She did her residency in Ophthalmology at Harvard and fellowships in Glaucoma (Mass Eye and Ear) and Medical Genetics (Tufts). Dr. Wiggs is clinically board certified in both Ophthalmology and Medical Genetics.
Dr. Wiggs is a physician scientist whose research program is dedicated to understanding the molecular mechanisms of glaucoma, including both early-onset glaucoma caused by highly penetrant alleles and common age-related glaucoma with complex inheritance. Dr. Wiggs is the PI of the NEIGHBORHOOD consortium contributing over 10,000 samples for genetic analyses.
Contact Information:
Phone: (617) 573-6906
janey_wiggs@meei.harvard.edu
Lab Manager
Kevin Linkroum graduated from Colby-Sawyer College in 2003 with a BA in Biology and concentrations in Chemistry and Film. After taking a year to pursue film studies, he joined Dr. Wiggs’ lab in 2004 as a research technologist and served in that capacity until 2008 when he became the Lab Manager for the Wiggs Lab and the Vision Core Facility.
Contact Information:
kevin_linkroum@meei.harvard.edu
Ophthalmology Instructor
Baojian Fan graduated in 2004 with a PhD degree, majoring in Molecular Genetics of Ophthalmology. He obtained a Master degree in Epidemiology & Biostatistics in 1997 and a Bachelor degree in Medicine (M.D. equivalent) in 1993.
Dr. Fan is primarily interested in gene mapping for Mendelian diseases (e.g., pigment dispersion syndrome) and complex diseases (e.g., adult-onset glaucoma). He is also interested in analysis of gene-gene and gene-environment interactions in complex diseases.
Dr. Fan is currently a PI on a grant given by the Massachusetts Lions Eye Research Fund to study the functional effects of the mutations in newly discovered genes responsible for pigment dispersion syndrome in zebrafish models. He is also a co-investigator on a NIH R01 grant to identify genes for ocular quantitative traits related to glaucoma using whole genome sequencing of large consanguineous pedigrees. He was a PI for a project funded by the BrightFocus Foundation to discover genetic variants that contribute to pigment dispersion syndrome and pigmentary glaucoma.
Contact Information:
baojian_fan@meei.harvard.edu
Research Fellow
Dr. Shisong Rong obtained his M.D. from the Capital Medical University in China and Ph.D. from the Chinese University of Hong Kong. Since his residency training in ophthalmology at Beijing Tongren Hospital, he has been actively involved in clinical & epidemiological studies and is engaged in studying the molecular genomics of eye diseases with a focus on glaucoma. He is now working with Dr. Janey Wiggs to bridge the gap in our knowledge about the biological links between genetic variants and glaucoma pathogenesis, identifying potential therapeutic targets for clinical translation.
Contact Information:
shisong_rong@meei.harvard.edu
Genetics Clinical Coordinator
Elizabeth DelBono earned a Masters of Public Health from Boston University with a concentration in research and epidemiology. Previously she worked in the Epidemiology Unit at MEE on retina research, including coordination for the initial Age Related Eye Disease Study (AREDS). In 2001 she joined Dr. Wiggs’ genetics research group at MEE. Her responsibilities include the identification, recruitment and consenting of potential study participants who are seen in the Glaucoma Service as well as maintaining clinical databases for the Wiggs Lab research projects. Other responsibilities include study documentation and reporting to the Human Studies Committee, and being a liaison between outside providers and OGI for GEDI-o testing.
Contact Information:
Elizabeth_delbono@meei.harvard.edu
Instructor in Ophthalmology
Dr. Aboobakar is a glaucoma clinician-scientist at Mass Eye and Ear. She earned her MD from Duke University School of Medicine, where she graduated at the top of her class and was inducted into the Alpha Omega Alpha medical honor society. She then completed a residency at Wilmer Eye Institute at Johns Hopkins and a 2-year glaucoma clinical and research fellowship at Mass Eye and Ear, during which she received the prestigious Heed Ophthalmic Foundation Fellowship and was named the Mass Eye and Ear Simmons Glaucoma Fellow. She has worked with Dr. Wiggs on a number of projects since the start of her glaucoma fellowship and is now a full-time faculty member in the Mass Eye and Ear Glaucoma division.
Dr. Aboobakar’s research aims to translate understanding of the genetic basis of glaucoma into clinical practice, in hopes of helping facilitate precision medicine approaches to disease diagnosis, risk stratification, monitoring and treatment. She is working on several projects that aim to 1) understand the clinical impact of disease-associated genetic variants using polygenic risk scores and deep clinical phenotyping, and 2) characterize the underlying functional mechanisms for gene variants in glaucoma development using cell-culture and animal models.
Inas_Aboobakar@meei.harvard.edu
Assistant Professor in Ophthalmology
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Dr. Rossin is a vitreoretinal surgeon and scientist in Mass Eye and Ear’s Retina Service. She is an Alumni of Harvard Medical School, where she also did her residency and fellowship. In addition to treating medical and surgical patients, she has received the K12 Mentored Clinical Scientist Development Program Award from the National Institutes of Health. Lizzy’s research focuses on disease genetics and methods to interpret the functional impact of mutations. She is currently working on a number of projects including:
– Application of network theory to analysis of protein structure in viral proteins to design mutation-resistant vaccines
– Network analysis of proteins linked to inherited retinal diseases to understand and discover causal variants
– RNA sequencing of patient-derived inflammatory retinal membranes that lead to retinal detachment (collaborator)
Elizabeth_Rossin@meei.harvard.edu
Post-Doctoral Research Fellow
Ma. Carmela Guevarra, MD
Dr. Guevarra is a glaucoma postdoctoral research fellow specializing in ocular genetics at Massachusetts Eye and Ear, Harvard Medical School. She earned her Medical Degree from the University of the East Ramon Magsaysay Memorial Medical Center and is a board-certified general practitioner in the Philippines. She completed one year of clinical ophthalmology training in Manila while actively contributing in the study genetics of early-onset glaucoma as a research assistant.
By utilizing next generation sequencing and genomic analysis, Dr. Guevarra aims to discover novel genetic mutations and understand the molecular mechanisms of glaucoma in the hope of providing future therapeutic advancements for those with underlying eye condition.
mguevarra@meei.harvard.edu