The Engle Laboratory, an HHMI molecular genetics and developmental neuroscience research lab at the Boston Children’s Hospital and affiliated with Harvard Medical School, has several themes:
- The CCDDs: Clinical and genetic studies of complex eye movement syndromes called the Congenital Cranial Dysinnervation Disorders (CCDDs).
- Axon Guidance: Neurodevelopmental studies of the genetic causes of the CCDDs. We have discovered that complex strabismus syndromes can be sensitive indicators of human genetic errors in axon growth and guidance. These include horizontal gaze palsy with progressive scoliosis, Duane syndrome, CFEOM1, and CFEOM3 that result from mutations in ROBO3, CHN1, KIF21A, and TUBB3 respectively.
- Strabismus: Genetic studies of the common forms of strabismus, including esotropia and exotropia.
To learn more about the research of the Engle Lab, please visit: http://www.childrenshospital.org/research-and-innovation/research/labs/engle-laboratory