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Dr. Eric Pierce Dr. Eric Pierce eric_pierce@meei.harvard.edu
Pierce Lab
Dr. Eric Pierce

Dr. Eric Pierce received his Ph.D. in Biochemistry from the University of Wisconsin-Madison and his M.D. from Harvard Medical School. He did his residency in Ophthalmology at Harvard and fellowship in Pediatric Ophthalmology at Children’s Hospital, Boston where he also took his first faculty position. He was then recruited to the department of Ophthalmology at the University of Pennsylvania School of Medicine, where he was promoted to Associate Professor with tenure. He returned to Harvard in 2011 to establish the Ocular Genomics Institute.

Dr. Pierce is an ophthalmologist and molecular geneticist whose research program is dedicated to understanding the molecular mechanisms of inherited retinal degenerations (IRDs), and improving therapeutic interventions for these conditions. IRDs are a leading cause of blindness worldwide, and are characterized by progressive dysfunction and death of retinal photoreceptor cells.

Dr. Pierce’s research program is focused on identifying new IRD disease genes, investigating the mechanism by which mutations in the identified genes lead to blindness, and using this information about disease pathogenesis to develop rational therapies to prevent vision loss.

Contact Information:

eric_pierce@meei.harvard.edu
Dr. Scott Greenwald Research Fellow scott_greenwald@meei.harvard.edu
Pierce Lab
Research Fellow

Dr. Scott Greenwald graduated from the University of Pennsylvania with a degree in the biological basis of behavior before joining Second Sight Medical Products to research the perceptual effects of artificial retinal stimulation in patients with advanced retinitis pigmentosa.  He went on to study cone photoreceptor dysfunction associated with inherited retinal diseases at the University of Washington where he earned a PhD in neurobiology.
Scott became a member of the Ocular Genomics Institute in 2013. He is investigating the role of the NMNAT1 enzyme in retinal cell metabolism and the mechanisms by which specific mutations in the NMNAT1 gene lead to an early-onset blinding disease called Leber congenital amaurosis (LCA).

Contact Information:

scott_greenwald@meei.harvard.edu
Dr. Revital Bronstein Research Fellow Revital_Bronstein@meei.harvard.edu
Pierce Lab
Research Fellow

Dr. Revital Bronstein completed her PhD at Tel-Aviv University, working with Professor Danny Segal on transcription complexes that regulate early development in Drosophila. More recently, she was a post-doctoral Fellow at the Weismann Institute of Science where her research with Professor Yuval Eshed focused on plant meristem identity and the regulation of flowering cycles.
Revital joined the Ocular Genomics Institute in the fall of 2015 as a post-doctoral Research Fellow. She is currently investigating the cellular and genetic processes underlying pathogenesis in splicing factor dependent retinitis pigmentosa.

Contact Information:

Revital_Bronstein@meei.harvard.edu
Basil Pawlyk Research Associate Basil_pawlyk@meei.harvard.edu
Pierce Lab
Research Associate

Basil Pawlyk graduated from the University of Massachusetts in 1977 with a Bachelor of Science degree in Biology/Chemistry. He then went on to earn a Master of Science degree (Neuroscience) from Northeastern University in 1982. His thesis work focused on CNS prostaglandin mediated pathways, which control body temperature and the febrile response to infection. During his graduate studies, Basil also participated in teaching General Physiology and Histology to undergraduates. Basil joined the Berman-Gund Laboratory of the MEEI in 1982 and focused on the functional (ERG) and structural (Histology) characterization of new animal models of RD. More recently, Basil’s work has involved evaluating various treatment strategies in mouse models of RD. This has included dietary supplementation (Vitamin A) in rhodopsin mutant mice and viral mediated gene augmentation therapy in a mouse model of X-linked RP and mouse models of LCA (AIPL1 and RPGRIP1). Basil is now a member of the Ocular Genomics Institute and is currently involved in Pre-Clinical animal studies related to RPGRIP1 LCA.

Contact Information:

Basil_pawlyk@meei.harvard.edu
Carol Weigel DiFranco Program Manager Carol_Weigel@meei.harvard.edu
Pierce Lab
Program Manager

Carol Weigel DiFranco, graduated from Regis College with a BA in Psychology and Tufts University with a MA in Child Study/Developmental Psychology with an emphasis on research, has worked with clinicians and researchers diagnosing and studying patients with Inherited Retinal Disorders since 1986. She served as the data manager of the Berman Gund , where she participated with Dr. Eliot Berson and colleagues in the design and execution of 3 clinical trials of nutritional supplements for patients with Retinitis Pigmentosa and several natural history studies for patients with Retinitis Pigmentosa and allied diseases. She also worked with patients and staff as the Manager of the Inherited Retinal Disorders Service . Currently she works with researchers in the Pierce Lab, OGI and Berman Gund Lab doing data management and facilitating the conduct of several clinical trials .She also provides administrative support to researchers in these labs.

Contact Information:

Carol_Weigel@meei.harvard.edu
Mike Scandura Research Technologist Michael_scandura@meei.harvard.edu
Pierce Lab
Research Technologist

Mike Scandura graduated from Tufts University in 2018 with a BS in Biology and a minor in History. As an undergraduate, he studied the relationship between psychosocial stress and alcoholism in adolescent mice as well as worked on an MGMT methylation study for patients with glioblastomas at Tufts Medical School.
Mike joined the Ocular Genomics Institute in September of 2018 as a research technologist for Dr. Scott Greenwald.

Michael_scandura@meei.harvard.edu
Heran Getachew Research Fellow Heran_Getachew@meei.harvard.edu
Pierce Lab
Research Fellow

Dr. Heran Getachew received her Ph.D. in Biomedical Sciences with an emphasis in Microbiology and Immunology from the University of Florida in September 2019. Her dissertation work focused on the intracellular survival mechanisms of an oral bacterium, Porphyromonas gingivalis, within cardiovascular cells in the context of atherosclerosis. She joined the Ocular Genomics Institute in November 2019 to study extracellular vesicles as a biomarker for retinal degenerations.

Heran_Getachew@meei.harvard.edu
Emily Brown Research Fellow emily_brown@meei.harvard.edu
Pierce Lab
Research Fellow

Affiliations: Broad Institute of MIT and Harvard; Harvard Ophthalmology.

Dr. Emily Brown obtained her undergraduate degree in Biological Sciences from the University of Connecticut. She went on to earn her PhD in Biomedical Sciences with concentrations in both Genetics and Clinical and Translational Science from the University of Florida in 2019. There she examined the molecular mechanisms of mitochondrial and metabolic dysfunction in the retina and how metabolic dysfunction may lead to age-related macular degeneration (AMD) and other retinal degenerative diseases. Emily joined the Ocular Genomics Institute in June 2019 as a Post-Doctoral Research Fellow

Emily’s current projects include:
1) Investigation of how mutations in NMNAT1, an enzyme involved in energy metabolism in all cell types, leads to an early-onset retinal degenerative disease known as Leber congenital amaurosis (LCA).
2) Development of AAV-mediated gene therapies for LCA caused by mutations in NMNAT1.
3) Identification of novel genetic causes of inherited retinal degenerations.

emily_brown@meei.harvard.edu

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