The Amamoto Lab at Mass Eye and Ear and the Ocular Genomics Institute studies how photoreceptors in the retina develop and degenerate, with the hope of one day developing a treatment to prolong healthy color vision for all patients suffering from inherited retinal degeneration.
Our team strives to tackle this goal in the following ways:
- Understanding the molecular mechanisms by which cone photoreceptors degenerate in a non-cell autonomous manner in mouse models of Retinitis Pigmentosa.
- Determining how to regenerate the photoreceptor outer segment by understanding how it develops in the first place.
- Developing new technologies to facilitate answering our questions in the molecular and cellular biology of the retina