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Ocular Genomics Institute Scientists publish large Gene-Wide Association Study of Glaucoma
March 2, 2021Janey WiggsAyellet Segre Janey Wiggs, MD, Ph.D., Ocular Genomics Institute Associate Director, Chief of Ophthalmology Clinical Research at Mass Eye and Ear, and the Paul Austin Chandler Professor of Ophthalmology and Vice Chair of Clinical Research at Harvard Medical School, and Ayellet Segre, genetic biostatistician, Ocular Genomics... Read More
First proof of concept for a therapy to treat patients with NMNAT1-associated disease
September 16, 2020Molecular Therapy: Methods & Clinical Development Vol. 18 September 2020 ª 2020 Authors from the Ocular Genomics Institute and Grousebeck Gene therapy Center have published the first proof of concept for a therapy to treat patients with NMNAT1-associated disease. No treatment is available for nicotinamide mononucleotide... Read More
Recent OGI Publications
June 12, 2020AAV-Mediated Gene Augmentation Therapy Restores Critical Functions in Mutant PRPF31+/− iPSC-Derived RPE... Read More
CRISPR trick in mice points the way to possible treatments for inherited diseases
March 8, 2018With the power of the genome-editing tool CRISPR on display, scientists around the world have been hard at work in recent years — developing CRISPR-based therapies that may one day edit disease-causing mutations in our DNA for the treatment of inherited disorders. But there are still great challenges with this powerful tool, and... Read More
Ocular Genomics Institute researchers find a connection between changes in the extracellular matrix of Bruch’s membrane and the activation of the Alternative Complement Pathway in Macular Degeneration.
November 3, 2017In a study published online this week in the Human Molecular Genetics journal, Drs. Rosario Fernandez-Godino, Dr. Kinga M. Bujakowska, and Dr. Eric Pierce of the Ocular Genomics Institute at the Massachusetts Eye and Ear, Harvard Medical School reported the remarkable finding that the formation of basal deposits in macular degeneration is... Read More
Editas Medicine Initiates Clinical Natural History Study to Evaluate Patients with Leber Congenital Amaurosis Type 10 (LCA10)
September 21, 2017Massachusetts Eye and Ear named as first site for the study CAMBRIDGE, Mass., Sept. 12, 2017 (GLOBE NEWSWIRE) -- Editas Medicine, Inc. (NASDAQ:EDIT), a leading genome editing company, today announced that the Company initiated a clinical natural history study of Leber Congenital Amaurosis type 10 (LCA10). LCA10 is caused by mutations... Read More
RETINAL Transcriptome
June 3, 2017Original work (2013) View Data in Genome Browser PROJECT DETAILS The human retinal transcriptome data, available on the UCSC Genome Browser, was derived by performing RNA-Seq on 3 normal retina samples. Over 300 million 101 bp paired-end reads were aligned using the RNA-Seq Unified Mapper . These data are available as a... Read More
Young New Zealander Visits the OGI
May 1, 2017Louis Corbett, front left, learns the latest in eye research from Dr. Luk Vandenberghe. Louis Corbett, 12, is losing his vision due to Retinitis Pigmentosa, an inherited retinal degeneration that also affects his older brother. His parents decided to take him on a “bucket-list” tour so he could see the world before his vision is permanently... Read More
GEDI Panel Released at MEEI
May 1, 2017The Massachusetts Eye and Ear/Harvard Medical School Department of Ophthalmology today announced the availability of a comprehensive genetic diagnostic test for inherited retinal disease (IRD), early-onset glaucoma and optic atrophy. The Massachusetts Eye and Ear/Harvard Medical School Department of Ophthalmology today announced the... Read More
GED-i Findings Published
May 1, 2017Mass. Eye and Ear Researchers Report that Panel-based Genetic Diagnostic Testing for Inherited Eye Diseases is Highly Accurate and More Sensitive than Exome Sequencing Findings published online in Genetics in Medicine BOSTON (November 20, 2014) Investigators at Massachusetts Eye and Ear and Harvard Medical School Department of... Read More