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Inas Aboobakar MD receives a Research to Prevent Blindness Career Development Award
January 14, 2025Dr. Aboobakar is a clinician-scientist in the Wiggs lab and Glaucoma Service at Mass Eye & Ear. With this grant she will be investigating the clinical features associated with mitochondrial copy number variation andheteroplasmy in primary open-angle glaucoma.
Optimized prime editing system successfully addressed the low efficiency often observed in hiPSCs
December 30, 2024The genetic background of a model may contain additional variants that contribute to the disease and complicate phenotype rescue. In this manuscript, we utilize prime editing technology to safely introduce point mutations into hiPSCs and generate isogenic disease models. With our optimized system, we successfully address the low efficiency... Read More
New Research on CFAP410-associated ciliopathy
November 21, 2024New publication by Riccardo Sangermano, PhD of the OGI’s Bujakowska lab, and colleagues reports on CFAP410- associated ciliopathy supporting its association with non-syndromic retinal degeneration. Read More
The Ocular Genomics Institute was well represented at the 2024 Iser meeting in Buenos Aires Argentina
October 31, 2024The following OGI members made presentations: Ayellet Segre PhD: GWAS and Transcriptomics riven drug repurposing for glaucoma Read More
Anil Chekuri Receives 2024 Iraty Award for Research in Retinal Diseases
October 31, 2024OGI investigator Anil Chekuri of the Grousbeck Gene Therapy Center and the Vandenberghe lab, is the 2024 Iraty Award which pays tribute to the life and work of Dr. Charles Schepens. The prize money will be used to support Anil's research, which aims to develop gene therapy to rescue retinal ganglion cell loss in familial dysautonomia Read More
Eric Pierce presents Lerner Lecture at Cleveland Clinic
October 31, 2024Eric Pierce MD PhD OGI director Eric Pierce presented ongoing research on the genetics of and the genetic therapies for inherited retinal degenerations at the 24th Lerner Lecture at the Cleveland Clinic in July. This prestigious lecture honors the late Chairman of the Cleveland Clinic Board. Previous Recipients have included eight Nobel... Read More
Gene Therapy Keynote speaker Eric Pierce
October 10, 2024Eric Pierce, director of the OGI will be the keynote speaker at the ARVO conference on Frontiers in Ocular Gene Therapy Research Conference. He will discuss the latest advancements, key challenges and future directions of gene therapy research for ophthalmic diseases and disorders. Read More
Genetic Finding leads to new hypotheses for treatment of Central Serous Chorioretinopathy.
September 27, 2024Elizabeth Rossin https://www.sciencedirect.com/science/article/abs/pii/S0002939424004082?dgcid=author
OGI Clinician Scientists recognized for excellence in clinical care and research
July 23, 2024Rachel Huckfeldt MD, PhD is among the 2024 honorees for the Anne Klibanski Visiting Scholars Award. This award is presented to women faculty clinicians, educators, researchers, and postdoctoral fellows who have demonstrated exceptional promise as leaders in their... Read More
OGI investigators validate new technique to predict pathogenic variants associated with inherited retinal disease
June 11, 2024Advances in gene sequencing technologies have accelerated the identification of genetic variants, but better tools are needed to understand which are causal of disease. This would be particularly useful in fields where gene therapy is a potential therapeutic modality for a disease-causing variant such as inherited retinal disease (IRD). Read More
CRISPR Gene Editing shown to be effective in improving vision
May 20, 2024Boston, Mass. — Results from a groundbreaking clinical trial of CRISPR gene editing in 14 individuals with a form of inherited blindness show that the treatment is safe and led to measurable improvements in 11 of the participants treated. The phase 1/2 trial called BRILLIANCE, was led by principal investigator Read More